COMPANY CONFIDENTIAL – NOT FOR EXTERNAL COMMUNICATION. PLEASE DO NOT FORWARD OUTSIDE OF ROCHE/GENENTECH. THE POLA LAUNCH COUNTDOWN HAS BEGUN. BE READY TO BE RELENTLESS! Get ready for promising new possibilities in DLBCL. Launch dates for POLATUZUMAB VEDOTIN are just around the corner: J‍une 2‍019 in the US and J‍anuary 2‍020 in the EU. Upside scenarios and corresponding commercial readiness dates are even closer: M‍arch 20‍19 in the US and Sep‍tember 2‍019 in the EU. This marks an amazing milestone for us here at Roche, and for Hematologists and Oncologists around the world. Most importantly, POLA will offer a new way for many patients with Relapsed/Refractory DLBCL to be relentless in their pursuit of survival, especially at the crucial point of first relapse. Many of you are busy putting together pre-launch and launch plans, outlining the required 20‍19 budget, and initiating internal and external awareness tactics. So let's get right to it. Here you'll find: • Your initial launch readiness guide • Key links to help you discover more about POLA • Outlines for key upcoming milestones The Path Ahead   Get ready for launch! Click to download the initial POLA Light Launch Readiness Guidance – a document building on the Integrated Plan 2019, which will help you with your brand planning process and your 2019 budget discussions, especially for early launching countries. We'll follow up with full guidance by the end of the year. Here are links to the previously provided cross-functional Integrated Plan for POLA (accessible through iPlan system) and the forecasting package. Start with "Launchpad Light" We've set up a "light" Launchpad platform to help you plan key launch milestones. It's simple to use, and includes key global dates you'll need to be aware of to define your local timelines. Be sure to fill out these important dates as relevant for your affiliates: Regulatory Approval, Special License Approval, Initial Shipment, Commercial Sales Start, Soft Commercial Launch, Commercial Launch, Access Submission and Reimbursement.   Please log on to the platform and complete these dates before 28th September.   LOG ON Awaken your inner expert If you missed the recent PolPosition Medical Education Event, you can find all presented materials, along with video recordings of all the presentations, here. Access event summary and presentations > Join us at the GIM!   The POLA & GAZYVA Global Implementation Meeting is fast approaching, so make plans now for Dublin, Ireland on 18th September. There, you'll learn more about the nuances of our POLA launch strategy and messaging platform. You'll also see detailed physician profiles to help you get ready for your local launch planning. You should have received your registration email, so be sure to register right away (password: Dublin)! Lots more information to come, but for now, let's get ready for our POLA launch and be ready to be relentless! Your POLA Global Team Information provided for internal planning purposes only. Action items and promotional strategies may be implemented only upon receipt of local jurisdiction's regulatory approval of the relevant product indication and following local affiliate legal/regulatory review. The controlling documents in any local jurisdiction are the local affiliate's approved plans. If you would like to withdraw your consent for inclusion in Roche electronic mail, click here. Click here for the Roche Privacy Policy.