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Discover more about the potential of HER2 Dimerization Inhibitors (HDIs)
Preclinical research continues to demonstrate the critical role of HER2 dimerization in HER2+ breast cancer.1
Inhibition of dimerization is a novel approach to targeting HER2. HER2 Dimerization Inhibitors (HDIs) are designed to inhibit the formation of HER2 dimers, including the HER2:HER3 dimer pair, which is a particularly potent activator of oncogenic
signaling.1,2
At SABCS, learn about the complex structure of HER2 and how this receptor mediates oncogenic signaling through multiple pathways.1,3 Discover why HER2 continues to be an active area of research.3
References: 1. Rosen LS, Ashurst HL, Chap L. Targeting signal transduction pathways in metastatic breast cancer: a comprehensive review. Oncologist. 2010;15:216-235. 2. Amin DN, Sergina N, Ahuja D, et al. Resiliency and vulnerability in the HER2-HER3 tumorigenic driver. Sci Transl Med. 2010;2:16ra7. 3. Sliwkowski MX. Ready to partner. Nat Struct Biol. 2003;10:158-159. 4. Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol. 2006;3:269-280.
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Discover for yourself what drives HER2+ disease.
Visit Booth 437 at SABCS. Activities include
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Build your own HER2 receptor
Discover how the complex structure of HER2 makes it a key receptor for dimerization and an important driver of HER2+ breast cancer.3
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Discover how receptors dimerize
Activate the formation of the HER2:HER3 dimer and witness its critical role in activating downstream oncogenic signaling in HER2+ breast cancer.1,2
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Inhibit dimerization
Can you inhibit HER2 dimer formation before the receptors come together? Learn more about the potential for HDIs.4
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Enter the world of HER2 at SABCS 2011, Booth 437
Henry B. Gonzalez Convention Center
200 E. Market Street
San Antonio, Texas 78205
December 6-10, 2011
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