Do you know the Hedgehog pathway? The Hedgehog pathway, normally inactive in adult tissue, can play a key role in the proliferation and growth of a variety of cancers, including basal cell carcinoma (BCC), when activated.1 Mutations in the Hedgehog pathway are implicated in over 90% of BCCs.2 What if we could cut the signals? Genentech is actively researching the potential of Hedgehog pathway inhibition and how it may fit into the therapeutic paradigms of various malignancies. For more information about the Hedgehog pathway and its components: References: 1. Scales SJ, de Sauvage FJ. Mechanisms of hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci. 2009;30:303-312. 2. Epstein EH. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer. 2008;8:743-754. Genentech BioOncology is proud to introduce ResearchHedgehog.com, providing an in-depth look at a novel targeted approach to inhibiting cancer growth.   Privacy Policy | Terms and Conditions | Contact Genentech® This e-mail is intended for U.S. healthcare professionals only. Genentech USA, Inc. 1 DNA Way South San Francisco, CA 94080-4990 © 2011 Genentech USA, Inc. All rights reserved. To unsubscribe from the Genentech BioOncology mailing list, please click here. HED0000461400 www.BioOncology.com